Antidepressant bone loss could be prevented with beta-blockers
Bone scans of mice after therapy with the antidepressant fluoxetine present that including the beta-blocker propranolol prevents bone loss. Credit score: Patricia Ducy, Ph.D., CUMC The antidepressant fluoxetine causes bone loss by instructing the mind to ship out alerts that enhance bone breakdown, however a beta-blocker can intercept the alerts, a brand new research in mice has discovered. The research was printed Sept. 5 in Nature Medication . Using selective serotonin-reuptake inhibitors (SSRIs), a category of medicine broadly prescribed for temper issues in addition to for nonpsychiatric situations, beforehand has been related to an elevated threat of bone fracture. The brand new research -- by Patricia Ducy, PhD, and colleagues at Columbia College Medical Middle -- revealed that fluoxetine, one of many most-prescribed SSRIs, acts on bone physiology via two distinct mechanisms . Initially, fluoxetine protects bone by inhibiting the...